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Active ingredient: Physostigmine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Cholinesterase Inhibitors
  • Miotics

Dosage Forms

  • Liquid

Brands / Synonyms

Antilirium; Cogmine Eserine; Erserine; Eserine; Eserine Salicylate; Eserine Sulfate; Eserolein, Methylcarbamate; Esromiotin; Ezerin; Fysostigmin; Isopto Eserine; Physostigmine; PHYSOSTIGMINE 9599; Physostol; Salicylate

Indications

For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity.

Pharmacology

Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma. Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. Physostigmine can reverse both central and peripheral anticholinergia.

Mechanism of Action

By interfering with the metabolism of acetylcholine, physostigmine indirectly stimulates both nicotinic and muscarinic receptors.

Absorption

Not Available

Toxicity

Side effects include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth, blurred vision or change in near or distant vision, and eye pain.

Biotrnasformation / Drug Metabolism

Quickly hydrolyzed by cholinesterases

Contraindications

Physostigmine Salicylate Injection should not be used in the presence of asthma, gangrene, diabetes, cardiovascular disease, mechanical obstruction of the intestine or urogenital tract or any vagotonic state, and in patients receiving choline esters and depolarizing neuromuscular blocking agents (decamethonium, succinyicholine).

For post-anesthesia, the concomitant use of atropine with physostigmine salicylate is not recommended, since the atropine antagonizes the action of physostigmine.

Drug Interactions

No information provided.

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