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Active ingredient: Phensuximide - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anticonvulsants
  • Antiepileptic Agents

Dosage Forms

  • Capsules

Brands / Synonyms

(+/-)-N-Methyl-2-phenylsuccinimide; 1-Methyl-3-Phenylsuccinimide; 7 Phenosuccimide; Epimid; Fenosuccimide; Fensuccimide [DCIT]; Fensuximida [INN-Spanish]; Lifene; Methylphenylsuccinimide; Milontin; Milontin (TN); Milonton; Mirontin; Mirotin; N-Methyl-2-phenylsuccinimide; N-Methyl-alpha-phenolsuccinimide; N-Methyl-alpha-phenylsuccinimide; Phensuximid; Phensuximide (USP); Phensuximide [BAN:INN]; Phensuximidum [INN-Latin]; Phenylsuximide; Succinimide, N-methyl-2-phenyl-; Succitimal


For the treatment of epilepsy


Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.

Mechanism of Action

Phensuximide's mechanism of action not understood, but may act in inhibitory neuronal systems that are important in the generation of the three per second rhythm


Rapid and complete


Not Available

Biotrnasformation / Drug Metabolism




- hypersensitivity to succinimides.

- Use cautiously with hepatic, renal abnormalities, acute intermittent porphyria, pregnancy (association between use of antiepileptic drugs by women with epilepsy and an elevated incidence of birth defects in children born to these women; however, antiepileptic therapy should not be discontinued in pregnant women who are receiving such therapy to prevent major seizures; the effect of even minor seizures on the developing fetus is unknown, and this should be considered when deciding whether to continue antiepileptic therapy in pregnant women), lactation.

Drug Interactions

Not Available

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