Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2D6
Primary Drug Target
Name
AMP-activated protein kinase (AMPK)
Gene Name
PRKAB1
Synonyms
5'-AMP-activated protein kinase, beta-1 subunit; AMPK beta-1 chain; AMPKb
Specific Function
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone- sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit