Active ingredient: Phenelzine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C8H12N2

Chemical Name

2-hydrazinylethylbenzene

Chemical Structure

Molecular Weight

136.194 g/mol

Physical State

Liquid

Melting Point

< 25 oC

Water Solubility

29.1 g/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Monoamine oxidase A (MAO-A)
Gene Name	MAOA
Synonyms	Amine oxidase [flavin-containing] A; EC 1.4.3.4; Monoamine oxidase type A; MAO-A
General Function	Amino acid transport and metabolism
Specific Function	Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAO-A preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Pathway	map00260 Glycine, serine and threonine metabolism map00330 Arginine and proline metabolism map00340 Histidine metabolism map00350 Tyrosine metabolism map00360 Phenylalanine metabolism map00380 Tryptophan metabolism
Reaction	RCH2NH2 + H2O + O2 = RCHO + ammonia + H2O2