Brands, Medical Use, Clinical Data
- Anti-Inflammatory Agents, Non-Steroidal
- Enzyme Inhibitors
Brands / Synonyms
For the relief of bladder pain or discomfort associated with interstitial cystitis.
Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects.
Mechanism of Action
Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Biotrnasformation / Drug Metabolism
Elmiron® (pentosan polysulfate sodium) is contraindicated in patients with known hypersensitivity
to the drug, structurally related compounds, or excipients.
Drug-Drug Interactions: Not studied.