Brands, Medical Use, Clinical Data
Drug Category
- Anabolic Agents
- Hormone replacement
Dosage Forms
- Solution (Subcutaneous Injection)
- Powder
Brands / Synonyms
GH; GH-N; Growth hormone; Growth hormone 1; Pituitary growth hormone; Somatotropin precursor; Somavert; Somavert (Pfizer Inc)
Description
Not Available
Indications
For treatment of acromegaly
Pharmacology
Somavert is used for the treatment of acromegaly, which arises from excessive IGF-1 levels. Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH, and thus interferes with GH signal transduction. Inhibition of GH action results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3). This reduces the symptoms of acromegaly.
Mechanism of Action
Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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