Brands, Medical Use, Clinical Data
- Anti-infective Agents
- Antineutropenic Agents
- Immunomodulatory Agents
Brands / Synonyms
Filgrastim; G-CSF; Granulocyte colony-stimulating factor precursor; Lenograstim; Neulasta; Neulasta (Amgen Inc.)
PEGylated (at N terminus) form of human G-CSF (Granulocyte colony stimulating factor), 175 residues, produced from E. coli via bacterial fermentation.
Increases leukocyte production, for treatment in non-myeloid cancer, neutropenia and bone marrow transplant
Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Pegfilgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. Pegfilgrastim has reduced renal clearance and prolonged persistence in vivo as compared to Filgrastim.
Mechanism of Action
Pegfilgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Pegfilgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Pegfilgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, pegfilgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase
Biotrnasformation / Drug Metabolism