Brands, Medical Use, Clinical Data
Brands / Synonyms
Alapav; Artegodan; Cardiospan; Cardoverina; Cepaverin; Cerebid; Cerespan; Chlorhydrate de Papaverine; Delapav; Dilaves; Dispamil; Drapavel; Durapav; Dynovas; Forpavin; Genabid; Myobid; Optenyl; Pameion; Pamelon; Panergon; Pap H; Papacon; Papalease; Papanerin; Papanerin-Hcl; Papanerine; Papavarine Chlorhydrate; Papaverin; Papaverine; Papaverine Chlorohydrate; Papaverine Hcl; Papaverine Hydrochloride; Papaverine Monohydrochloride; Papaverine, Hydrochloride; Papaverinium Chloride; Papaversan; Papital T.R.; Paptial T.R.; Pavabid; Pavabid Hp; Pavacap; Pavacels; Pavacen; Pavacot; Pavadel; Pavagen; Pavakey; Pavarine; Pavased; Pavatest; Pavatine; Pavatym; Paverolan; Paveron; Pavnell; Qua Bid; Ro-Papav; Robaxapap; Spasmo-Nit; Therapav; Vasal; Vaso-Pav; Vasospan
For the treatment of impotence
Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Papaverine are exerted on cardiac and smooth muscle. Like qathidine, Papaverine acts directly on the heart muscle to depress conduction and prolong the refractory period. Papaverine relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Papaverine and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Papaverine is practically devoid of effects on the central nervous system. Papaverine relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries.
Mechanism of Action
Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy.
Biotrnasformation / Drug Metabolism
Intravenous injection of papaverine is contraindicated in the presence of complete atrioventricular heart block.
When conduction is depressed, the drug may produce transient ectopic rhythms of ventricular origin, either premature
beats or paroxysmal tachycardia.
Papaverine hydrochloride is not indicated for the treatment of impotence by intracorporeal injection. The
intracorporeal injection of papaverine hydrochloride has been reported to have resulted in persistent priapism
requiring medical and surgical intervention.
No information provided.