Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
Brands / Synonyms
FGF-7; Fibroblast growth factor- 7; HBGF-7; Kepivance; Kepivance (Amgen Inc)
; Keratinocyte growth factor precursor; KGF
Description
Human keratinocyte growth factor (KGF), 140 residues long, expressed in E. coli. First 23 residues removed to improve stability.
Indications
For treatment of mucositis (mouth sores)
Pharmacology
Used in the prevention or treatment of oral mucoscitis (mouth ulcers arising from chemotherapy), Kepivance binds to the human keratinocyte growth factor (KGF) receptor on buccal cell surfaces. Kepivance acts as both a cell growth and survival factor by stimulating epithelial cell proliferation, differentiation, and migration around the tongue and mouth. The KGF receptor is found on many tissues particularly around the tongue, esophagus, salivary gland and other gastro-intestinal tract organs.
Mechanism of Action
Kepivance binds to the human keratinocyte growth factor (KGF) receptor found on buccal cell surfaces. The binding activates a Ras-MapK (Map kinase) signaling pathway which leads to the transcriptional activation of many proteins important for cell growth and survival.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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