Chemisty and Biological Activity
Chemical Formula
C47H51NO14
Chemical Name
5 beta,20-Epoxy-1,2a,4,7 beta,10 beta,13 alpha-hexahydroxytax-11-en-9- one 4,10-diacetate 2-benzoate 13-ester with (2 R,3S)-N-benzoyl-3- phenylisoserine
Chemical Structure
Molecular Weight
853.906 g/mol
Physical State
Solid
Melting Point
213-216 oC
Water Solubility
Insoluble
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2C8; CYP3A4
Primary Drug Target
Name | Apoptosis regulator Bcl-2 | Gene Name | BCL2 | Synonyms | Tubulin beta-1 chain | Specific Function | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) |
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