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Active ingredient: Paclitaxel - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

5 beta,20-Epoxy-1,2a,4,7 beta,10 beta,13 alpha-hexahydroxytax-11-en-9- one 4,10-diacetate 2-benzoate 13-ester with (2 R,3S)-N-benzoyl-3- phenylisoserine

Chemical Structure

Molecular Weight

853.906 g/mol

Physical State


Melting Point

213-216 oC

Water Solubility


Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameApoptosis regulator Bcl-2
Gene NameBCL2
SynonymsTubulin beta-1 chain
Specific FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)

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