Brands, Medical Use, Clinical Data
- Anti-Asthmatic Agents
- Immunomodulatory Agents
Brands / Synonyms
Ig gamma-1 chain C region; Xolair; Xolair (Genentech Inc)
A recombinant DNA-derived humanized IgG1 monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
For treatment of asthma caused by allergies
Xolair inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Xolair is used to treat severe, persisten asthma.
Mechanism of Action
Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
Biotrnasformation / Drug Metabolism
Most likely removed by opsonization via the reticuloendothelial system.