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Active ingredient: Norethindrone - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Contraceptives, Oral, Synthetic
  • Progestins

Dosage Forms

  • Tablet

Brands / Synonyms

Anhydrohydroxynorprogesterone; Anovulatorio; Anovule; Aygestin; Binovum; Brevicon; Brevinor; Brevinor 21; Brevinor 28; Brevinor-1 21; Brevinor-1 28; Camila; Ciclovulan; Combipatch; Conceplan; Conludaf; Conludag; Demulen; ENT; Errin; Estrinor; Estrostep FE; Ethinylnortestosterone; Ethynylmortestosterone; Ethynylnortestosterone; Femhrt; Gencept; Genora; Gestest; Jenest; Jenest-28; Junel; Leena; Levlen; Loestrin; Menzol; Microneth; Micronett; Micronor; Micronovum; Milli; Mini-Pe; Mini-Pill; Minovlar; Modicon; N.E.E.; Necon; Nelova; Neocon; NET; Nodiol; Nor-Q.D.; NOR-QD; Nora-BE; Noraethisteronum; Noralutin; Norcept; Norcept-E; Norcolut; Nordette; Noresthisterone; Norethadrone; Norethin; Norethin 1/35 E; Norethin 1/50 M; Norethindrone Acetate; Norethindrone Norethisterone; Norethisteron; Norethisterone; Norethisterone [Progestins]; Norethisteronum [Inn-Latin]; Norethyndron; Norethynodron; Norethynodrone; Noretisterona [Inn-Spanish]; Noretisterone [Dcit]; Norfor; Norgestin; Noriday; Noriday 28; Norimin; Norinyl; Norlestrin; Norlutate; Norluten; Norlutin; Norluton; Normapause; Norpregneninlone; Norpregneninolone; Norpregneninotone; Nortrel 7 / 7 / 7; Orlest; Ortho 1 35; Ortho 7 7 7; Ortho Micronor; Ortho-Novum; Ortho-Novum 1 35; Ortho-Novum 1 50; Ortho-Novum 7 7 7; Ovcon; Ovral; Ovrette; Ovysmen; Ovysmen 0.5 35; Ovysmen 1 35; Palonyl; Perovex; Primolut N; Primolut-N; Proluteasi; Synphase; Synphasic 28; Tri-Levlen; TRI-Norinyl; Triella; Trinovum; Trinovum 21; Utovlan; Utovlar

Indications

For use as an oral contraceptive in the prevention of pregnancy.

Pharmacology

Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen.

Mechanism of Action

Progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.

Absorption

Absolute oral bioavailability approximately 64%

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Hepatic

Contraindications

Progestin-only oral contraceptives (POPs) should not be used by women who currently have the following conditions:

  • Known or suspected pregnancy
  • Known or suspected carcinoma of the breast
  • Undiagnosed abnormal genital bleeding
  • Hypersensitivity to any component of this product
  • Benign or malignant liver tumors
  • Acute liver disease

Drug Interactions

The effectiveness of progestin-only pills is reduced by hepatic enzyme-inducing drugs such as the anticonvulsants phenytoin, carbamazepine, and barbiturates, and the antituberculosis drug rifampin. No significant interaction has been found with broad-spectrum antibiotics.

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