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Active ingredient: Nifedipine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C17H18N2O6

Chemical Name

dimethyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylate

Chemical Structure

Molecular Weight

346.335 g/mol

Physical State

Solid

Melting Point

172 - 174 oC

Water Solubility

Insoluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
Name1,4-dihydropyridine Receptor on alpha1 subunit of L-type voltage sensitive Ca2+ channels
Gene NameCACNA2D1
SynonymsDihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunits precursor
General FunctionCell motility
Specific FunctionCalcium channel protein which plays an important role in excitation-contraction coupling

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