Chemisty and Biological Activity
Chemical Formula
C26H29N3O6
Chemical Name
methyl2-(benzyl-methyl-amino)ethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate
Chemical Structure
Molecular Weight
479.525 g/mol
Physical State
Solid
Melting Point
136-138 oC
Water Solubility
2.2 mg/L
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
| Name | Voltage-dependent L-type calcium channel alpha-1C subunit | | Gene Name | CACNA1C | | Synonyms | Voltage-dependent L-type calcium channel alpha-1C subunit; Voltage-gated calcium channel alpha subunit Cav1.2; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | | General Function | Transport activities | | Specific Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the "high-voltage activated" (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds |
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