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Active ingredient: Mirtazapine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C17H19N3

Chemical Name

1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3- c][2]benzazepine

Chemical Structure

Molecular Weight

265.353 g/mol

Physical State

Solid

Melting Point

114-116oC

Water Solubility

Slight

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP1A2; CYP3A4; CYP2D6

Primary Drug Target
Name5-hydroxytryptamine 2A receptor
Gene NameHTR2A
Synonyms5-HT-2A; Serotonin receptor 2A; 5- HT-2
Specific FunctionThis is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

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