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Active ingredient: Methylprednisolone - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Neuroprotective Agents
  • Glucocorticoids
  • Antiemetics
  • Anti-inflammatory Agents
  • Adrenergic Agents

Dosage Forms

  • Tablets
  • Suspension

Brands / Synonyms

; 6alpha-Methylprednisolone; A-Methapred; Artisone-Wyeth; Besonia; Cortalone; Delta-Cortef; Depo-Medrol; Dopomedrol; Esametone; Fernisolone-P; Firmacort; Lemod; M-Predrol; Medesone; Medixon; Medlone 21; Medrate; Medrol; Medrol Acetate; Medrol Adt Pak; Medrol Dosepak; Medrone; MEPRDL; Mesopren; Metastab; Methyleneprednisolone; Methylprednisolon; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Sodium Succinate; Methylprednisolone, Pharma; Methylprednisolonum [Inn-Latin]; Meti-Derm; Metilbetasone; Metilprednisolona [Inn-Spanish]; Metilprednisolone [Dcit]; Metrisone; Metrocort; Metysolon; Moderin; Nirypan; Noretona; Predni N Tablinen; Prednisolone; Prelone; Promacortine; Reactenol; Sieropresol; Solomet; Solu-Medrol; Sterane; Summicort; Suprametil; Urbason; Urbasone; Wyacort


Adjunctive therapy for short-term administration in rheumatoid arthritis.


Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.

Mechanism of Action

Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.


Oral bioavailability 80-99%


LD50=2000 mg/kg (orally in rat)

Biotrnasformation / Drug Metabolism



Systemic fungal infections and known hypersensitivity to components.

Drug Interactions

The pharmacokinetic interactions listed below are potentially clinically important. Mutual inhibition of metabolism occurs with concurrent use of cyclosporin and methylprednisolone; therefore, it is possible that adverse events associated with the individual use of either drug may be more apt to occur. convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin, and rifampin may increase the clearance of methylprednisolone and may require increased in methylprednisolone dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of methylprednisolone and thus decrease its clearance. Therefore, the dose of methylprednisolone should be titrated to avoid steroid toxicity.

Methylprednisolone may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when methylprednisolone is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia.

The effect of methylprednisolone on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulant when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

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