Brands, Medical Use, Clinical Data
Drug Category
- Muscle Relaxants, Central
Dosage Forms
- Liquid (100 mg/mL in 10 mL vials)
- Tablet (500 mg and 750 mg) for oral administration
Brands / Synonyms
AHR 85; Avetil; Delaxin; Etroflex; Forbaxin; Glycerylguaiacolate carbamate; Glycerylguajacol-Carbamat; Guaiacol glyceryl ether carbamate; Guaiphenesin carbamate; Guaiphenesine carbamate; Lumirelax; Methocal; Methocarbamol; Metocarbamol; Metocarbamolo; Metofenia; Metofenina; Miolaxene; Miorilas; Miowas; Myolaxene; Neuraxin; Parabaxin; Perilax; Reflexyn; Relax; Relestrid; Robamol; Robaxan; Robaxin; Robaxine; Robaxon; Robinax; Romethocarb; Surquetil; Traumacut; Tresortil
Indications
For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.
Pharmacology
Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.
Mechanism of Action
The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Absorption
Rapid. Onset of action is about 30 minutes after oral administration.
Toxicity
Symptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.
Biotrnasformation / Drug Metabolism
Hepatic.
Contraindications
Methocarbamol Tablets are contraindicated in patients hypersensitive to any of the ingredients.
Drug Interactions
No information available.
|
