Active ingredient: Methacycline - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Anti-bacterial Agents

Dosage Forms

• Not Available

Brands / Synonyms

Metacycline; Methacyclin; Rondomycin

Indications

For the treatment of acute bacterial exacerbations of chronic bronchitis

Pharmacology

Methacycline, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Methacycline is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.

Mechanism of Action

Methacycline is first metabolized to 14-OH Methacycline. Like other macrolides, it then binds to the 50 S subunit of the 70 S ribosome of the bacteria, blocking RNA-mediated bacterial protein synthesis. Methacycline also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available