Brands, Medical Use, Clinical Data
- Anti-Anxiety Agents
- Hypnotics and Sedatives
- Muscle Relaxants, Central
- Tablet for oral administration (200 mg, 400 mg)
Brands / Synonyms
3P bamate; Amepromat; Amosene; Anastress; Anathylmon; Anatimon; Andaksin; Andaxin; Aneural; Aneurol; Aneusral; Aneuxal; Aneuxral; Ansiatan; Ansietan; Ansil; Ansiowas; Anural; Anxietil; Anzil; Apascil; Apasil; Apo-Meprobamate; Appetrol; Appetrol-Sr; Arcoban; Arpon; Artolon; Ataraxine; Atraxin; Auxietil; Ayeramate; Ayermate; Bamate; Bamd 400; Bamo 400; Biobamat; Biobamate; Brobamate; Calmadin; Calmax; Calmiren; Canquil 400; Canquil-400; Carbaxin; Cirpon; Cirponyl; Coprobate; Crestanil; Cypron; Cyrpon; Dapaz; DEA No. 2820; Deprol; Despasmol; Dicandiol; Diron; Diurnal; Diurnaldiverondormabrol; Diveron; Dormabrol; Ecuanil; Edenal; Enorden; Epicur; Epikur; Equagesic; Equanil; Equanil suspension; Equatrate; Equazine-M; Equilium; Equinil; Equitar; Erina; Estasil; Fas-Cile; Fas-Cile 200; Gadexyl; Gagexyl; Harmonin; Hartol; Holbamate; Ipsotian; Kesso-Bamate; Kessobamate; Klort; Larten; Lepenil; Lepetown; Letyl; Libiolan; Madiol; Mar-Bate; Margonil; Mendel; Mepamtin; Mepantin; Mepavlon; Mepiosine; Meposed; Mepranil; Mepriam; Meprin; Meprindon; Mepro-analgesic; Mepro-Aspirin; Meprobam; Meprobamat; Meprobamat [German]; Meprobamate; Meprobamate and Aspirin Tablets; Meprobamate [USAN:BAN:INN:JAN]; Meprobamato; Meprobamato [INN-Spanish]; Meprobamato [Italian]; Meprobamatum [INN-Latin]; Meproban; Meprocompren; Meprocon; Meprocon CMC; Meprodil; Meprodiol; Meprol; Meproleaf; Mepron; Mepronil; Meprosa; Meprosan; Meprosin; Meprospan; Meprospan 200; Meprospan 400; Meprospan-200; Meprospan-400; Meprotabs; Meprotan; Meprotanum; Meproten; Meprotil; Meprovan; Meprovanmeprozine; Meprozine; Meptran; Meptranactylmilprem; Mesmar; Metractyl; Metranquil; Micrainin; Milpath; Milprem; Milprem-200; Milprem-400; Miltamato; Miltann; Miltaun; Miltown; Miltown 600; Miltown-200; Miltown-400; Miltown-600; Miltrate; Miltuan; Miltwon; Misedant; Morbam; Multaun; My-trans; Neo-Tran; Nephentine; Nervonus; Neuramate; Oasil; Optarket; Orlevol; Orolevol; Pan-tranquil; Pancalma; Panediol; Pankalma; Pathibamate; Paxin; Pensive; Perequietil; Perequil; Perquietil; Pertranquil; Pimal; Placidon; Placitate; Prequil; Probamato; Probamyl; Probate; Procalmadiol; Procalmadol; Procalmidol; Procarbamide; Promate; Promato; Proquanil; Protran; Q-Gesic; Quaname; Quanane; Quanil; Quietidon; Quivet; Rastenil; Reostral; Restenil; Restenyl; Restinal; Restinil; Restran; Robamate; Sadanyl; Scolazil; Sedabamate; Sedanil; Sedanyl; Sedazil; Sedoquil; Sedoselecta; Selene; Seril; Setran; Shalvaton; SK-Bamate; Solevione anastress; Sowell; Spantran; Stensolo; Tamate; Tensol; Tensonal; Trancot; Trankvilan; Tranlisant; Tranmep; Tranquil; Tranquilan; Tranquilate; Tranquilax; Tranquiline; Tranquillin; Tranquilsan; Tranquinol; Tranquisan; Trelmar; Urbil; Urbilat; Vio-Bamate; Vistabamate; Wardamate; Wyseals; Zirpon
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.
Meprobamate is an anxiolytic drug. It was the best selling minor tranquilizer for a time but has largely been replaced by benzodiazepines. Meprobamate has most of the pharmacological effects and dangers of the barbiturates (though it was marketed as being safer). However, it is less sedating at effective doses. It is reported to have some anticonvulsant properties against absence seizures, but can exacerbate generalized tonic-clonic seizures. It has also been used as a hypnotic (sleeping pill). However, its is currently only licensed as an anxiolytic and it is a third or fourth-order choice.
Mechanism of Action
The mechanism of action is not known. Meprobamate is a carbamate derivative which has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Rather than acting directly on skeletal muscle, meprobamate interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception.
Well absorbed from the gastrointestinal tract.
Symptoms of overdose include coma, drowsiness, loss of muscle control, severely impaired breathing, shock, sluggishness, and unresponsiveness. Death has been reported with ingestion of as little as 12 g meprobamate and survival with as much as 40 g.
Biotrnasformation / Drug Metabolism
Acute intermittent porphyria as well as allergic or idiosyncratic reactions to meprobamate or related compounds
such as carisoprodol, mebutamate, tybamate or carbromal.
No Information Provided.