Chemisty and Biological Activity
Chemical Formula
C12H14N2O2
Chemical Name
5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione
Chemical Structure
Molecular Weight
218.252 g/mol
Physical State
Solid
Melting Point
135 oC
Water Solubility
1270 mg/L
Isoelectric Point
8.51
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP2B6
Primary Drug Target
| Name | Voltage-gated sodium channel | | Gene Name | SCN5A | | Synonyms | Sodium channel protein type V alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.5; Sodium channel protein, cardiac muscle alpha-subunit; HH1 | | Specific Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram |
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