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Active ingredient: Mephenytoin - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anticonvulsants

Dosage Forms

  • Tablet

Brands / Synonyms

Dilantin; Dilantin-125; Epiazin; Epilan; Fenantoin; Gerot-Epilan; Insulton; Mephentoin; Mesantoin; Mesdontoin; Mesontoin; Methoin; Methyl Hydantoin; Methylphenetoin; Metydan; Phenantoin; Phentytoin; Phenylethylmethylhydantoin; Phenytoin; Sacerno; Sedantional; Sedantoin; Sedantoinal; Triantoin


For the treatment of refractory partial epilepsy.


Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.

Mechanism of Action

The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.


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Biotrnasformation / Drug Metabolism

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Drug Interactions

Drug Interactions:

Some anticonvulsants may interact with Mephenytoin. They can either increase or
decrease the effect of Mephenytoin. Those anticonvulsants include divalproex sodium, valproic acid, and

Mephenytoin may also affect the effects of other drugs, which include some steroid medications,
warfarin, certain heart medicines, birth control pills, anti-infective medicines, furosemide and theophylline

Please note that Mephenytoin may interact with other drugs that are not listed here.

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