Active ingredient: Mefenamic Acid - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C15H15NO2

Chemical Name

2-(2,3-dimethylphenyl)aminobenzoic acid

Chemical Structure

Molecular Weight

241.285 g/mol

Physical State

Solid

Melting Point

230-231 oC

Water Solubility

20 mg/L

Isoelectric Point

4.2

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2C9

Primary Drug Target

Name	COX-2 (Prostaglandin G/H synthase 2)
Gene Name	PTGS2
Synonyms	Prostaglandin G/H synthase 2 precursor; EC 1.14.99.1; Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II
Specific Function	May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity
Pathway	map00590 Prostaglandin and leukotriene metabolism
Reaction	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O