Basic Profile / Key Facts
Drug Category
- Topical anti-inflammatory Agent
Dosage Forms
Indications
For the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity.
Pharmacology
Medrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use. In patients with increased intraocular pressure and in those susceptible to a rise in intraocular pressure, there is less effect on pressure with medrysone than with dexamethasone or betamethasone. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.
Mechanism of Action
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Absorption
Rapidly absorbed following oral administration.
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
HMS® (medrysone) is contraindicated in the following conditions:
Acute superficial herpes simplex
Viral diseases of the conjunctiva and cornea
Ocular tuberculosis
Fungal diseases of the eye
Hypersensitivity to any of the components of the drug
Drug Interactions
No Informatuion Provided.
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