Active ingredient: Losartan - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C22H23ClN6O

Chemical Name

[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H- imidazol-4-yl]methanol

Chemical Structure

Molecular Weight

422.911 g/mol

Physical State

Solid

Melting Point

183.5-184.5 oC

Water Solubility

0.82 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4; CYP2C9

Primary Drug Target

Name	Type-1 angiotensin II Receptor (AT1)
Gene Name	AGTR1
Synonyms	Type-1 angiotensin II receptor; AT1; AT1AR
Specific Function	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system