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Active ingredient: Lorazepam - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca- 5,8,10,12-tetraen-3-one

Chemical Structure

Molecular Weight

321.158 g/mol

Physical State


Melting Point


Water Solubility

0.08 mg/mL

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

UDP-glucuronic acid

Primary Drug Target
NameBenzodiazepine Receptor
Gene NameBZRP
SynonymsPeripheral-type benzodiazepine receptor; PBR; PKBS; Mitochondrial benzodiazepine receptor
General FunctionSignal transduction mechanisms
Specific FunctionResponsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme

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