Chemisty and Biological Activity
Chemical Formula
C14H22N2O
Chemical Name
2-diethylamino-N-(2,6-dimethylphenyl)-ethanamide
Chemical Structure
Molecular Weight
234.337 g/mol
Physical State
Solid
Melting Point
68.5oC (boiling point 181oC)
Water Solubility
4100 mg/L
Isoelectric Point
8.01
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP1A2; CYP2D6
Primary Drug Target
| Name | Voltage-gated sodium channel | | Gene Name | SCN5A | | Synonyms | Sodium channel protein type V alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.5; Sodium channel protein, cardiac muscle alpha-subunit; HH1 | | Specific Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram |
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