Chemisty and Biological Activity
Chemical Formula
C9H7Cl2N5
Chemical Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Chemical Structure
Molecular Weight
256.091 g/mol
Physical State
Solid
Melting Point
216-218 oC (uncorr)
Water Solubility
Not Available
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | Voltage-gated sodium channel | | Gene Name | SCN5A | | Synonyms | Sodium channel protein type V alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.5; Sodium channel protein, cardiac muscle alpha-subunit; HH1 | | Specific Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram |
|
