Chemisty and Biological Activity
Chemical Formula
C18H36N4O11
Chemical Name
2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6- (hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]- tetrahydropyran-3,4,5-triol
Chemical Structure
Molecular Weight
484.499 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Not Available
Isoelectric Point
Not Available
Organisms Affected
Enteric bacteria and other eubacteria
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Aminoglycoside 2'-N-Acetyltransferase; Kanamycin Nucleotidyltransferase; Aminoglycoside 3'-Phosphotransferase
Primary Drug Target
| Name | 30S ribosomal protein S12 | | Gene Name | rpsL | | Synonyms | 30S ribosomal protein S12 | | General Function | Translation, ribosomal structure and biogenesis | | Specific Function | Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit. |
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