Brands, Medical Use, Clinical Data
- Cardiotonic Agents
- Bronchodilator Agents
Brands / Synonyms
Aerolone; Aleudrin; Aleudrine; Aludrin; Aludrine; Asiprenol; Asmalar; Assiprenol; Bellasthman; Bronkephrine; Dihydroxyphenylethanolisopropylamine; DUO-Medihaler; Epinephrine Isopropyl Homolog; Euspiran; IPA; Isadrine; Isonorene; Isonorin; Isoprenalin; Isopropydrin; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol Chloride; Isoproterenol HCl; Isorenin; Isuprel; Isuprel Mistometer; Isupren; L-Isopropylnoradrenaline; L-Isoproterenol; Lomupren; Medihaler-Iso; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine; Neo-Epinine; Neodrenal; Norisodrine; Norisodrine Aerotrol; Novodrin; Proternol; Respifral; Saventrine; Vapo-Iso
For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
Isoproterenol is a relatively selective beta2-adrenergic bronchodilator. Isoproterenol is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Isoproterenol, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Mechanism of Action
The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Biotrnasformation / Drug Metabolism
Use of isoproterenol hydrochloride injection is contraindicated in patients with tachyarrhythmias; tachycardia or
heart block caused by digitalis intoxication; ventricular arrhythmias which require inotropic therapy; and angina
Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously because both drugs
are direct cardiac stimulants and their combined effects may induce serious arrhythmias. The drugs may, however, be
administered alternately provided a proper interval has elapsed between doses.
ISUPREL should be used with caution, if at all, when potent inhalational anesthetics such as halothane are
employed because of potential to sensitize the myocardium to effects of sympathomimetic amines.