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Active ingredient: Isoflurophate - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antiglaucomic Agents
  • Ophthalmics
  • Cholinesterase Inhibitors
  • Miotics
  • Protease Inhibitors

Dosage Forms

  • Not Available

Brands / Synonyms

DFP; Diflupyl; Diflurophate; Diisopropoxyphosphoryl Fluoride; Diisopropyl Cyanomethylphosphonate,; Diisopropyl Fluoridophosphate; Diisopropyl Fluorophosphate; Diisopropyl Fluorophosphonate; Diisopropyl Phosphofluoridate; Diisopropyl Phosphorofluoridate; Diisopropylfluorfosfat; Diisopropylfluorfosfat [Czech]; Diisopropylfluorophosphoric Acid Ester; Diisopropylfluorphosphorsaeureester; Disiopropyl Fluorophosphonate; Dyflos; Floropryl; Fluorodiisopropyl Phosphate; Fluoropryl; Fluostigmine; Fluropryl; Humorsol; Isofluorophate; Isofluorphate; Isoflurophosphate; Isopropyl Fluophosphate; Isopropyl Phosphorofluoridate; Neoglaucit; O,O-Diisopropyl Fluorophosphate; PF-3; Phospholine Iodide; Rcra Waste No. P043; Rcra Waste Number P043

Indications

For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.

Pharmacology

Isoflurophate is used as ocular drops in the treatment of chronic glaucoma. Isoflurophate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isoflurophate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Isoflurophate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.

Mechanism of Action

The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.

Absorption

Not Available

Toxicity

Signs of overdose include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth.

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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