Brands, Medical Use, Clinical Data
Drug Category
- Bronchodilator Agents
- Adrenergic beta-Agonists
Dosage Forms
- Inhalation aerosol
- Inhalation solution
Brands / Synonyms
Beta-2; Bronkometer; Bronkosol; Dey-Lute Isoetharine; Dilabron; Etyprenaline; Isoetarin; Isoetarina [Inn-Spanish]; Isoetarine; Isoetarinum [Inn-Latin]; Isoetharine Hcl; Isoetharine HCl S/F; Isoetharine mesylate; Neoisuprel
Indications
For the treatment of asthma, wheezing, and chronic asthmatic bronchitis.
Pharmacology
Isoetharine is a relatively selective beta2-adrenergic bronchodilator. Isoetharine is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. Adrenergic bronchodilators are breathed in through the mouth to open up the bronchial tubes (air passages) of the lungs.
Mechanism of Action
The pharmacologic effects of isoetharine are attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Absorption
Not Available
Toxicity
Signs of overdose include tachycardia, palpitations, nausea, headache, and epinephrine-like side effects.
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Contraindicated in the following: heart or blood vessel disease (these
medicines may make these conditions worse), high blood pressure, not well controlled (may make this condition worse),
overactive thyroid, and pheochromocytoma diagnosed or suspected (the chance of side effects may be increased).
Drug Interactions
May interact with the following: beta-adrenergic blocking agents (these
medicines may make your condition worse and prevent the adrenergic bronchodilators from working properly) and
disopyramide, quinidine, phenothiazines, and procainamide (these medicines may increase the risk of heart problems).
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