Active ingredient: Irinotecan - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C33H38N4O6

Chemical Name

irinotecan hydrochloride

Chemical Structure

Molecular Weight

586.678 g/mol

Physical State

Solid

Melting Point

222-223 oC

Water Solubility

Soluble

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target

Name	DNA Topoisomerase I
Gene Name	TOP1MT
Synonyms	DNA topoisomerase I, mitochondrial precursor; EC 5.99.1.2; TOP1mt
General Function	Replication, recombination and repair
Specific Function	Relieves DNA strain that arise during duplication of mitochondrial DNA
Reaction	ATP-independent breakage of single-stranded DNA, followed by passage and rejoining