Active ingredient: Irbesartan - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C25H28N6O

Chemical Name

2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3- diazaspiro[4.4]non-1-en-4-one

Chemical Structure

Molecular Weight

428.53 g/mol

Physical State

Solid

Melting Point

180-181 oC

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2C9

Primary Drug Target

Name	Type-1 angiotensin II Receptor (AT1)
Gene Name	AGTR1
Synonyms	Type-1 angiotensin II receptor; AT1; AT1AR
Specific Function	Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system