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Active ingredient: Ibuprofen - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

2-[4-(2-methylpropyl)phenyl]propanoic acid

Chemical Structure

Molecular Weight

206.281 g/mol

Physical State


Melting Point

75 - 77 oC

Water Solubility

0.049 mg/ml

Isoelectric Point


Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
Gene NamePTGS1
SynonymsProstaglandin G/H synthase 1 precursor; EC; Cyclooxygenase- 1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1
Specific FunctionMay play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells
Pathwaymap00590 Prostaglandin and leukotriene metabolism
Reactionarachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

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