Active ingredient: Ibuprofen - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C13H18O2

Chemical Name

2-[4-(2-methylpropyl)phenyl]propanoic acid

Chemical Structure

Molecular Weight

206.281 g/mol

Physical State

Solid

Melting Point

75 - 77 oC

Water Solubility

0.049 mg/ml

Isoelectric Point

4.91

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2C9

Primary Drug Target

Name	COX-1
Gene Name	PTGS1
Synonyms	Prostaglandin G/H synthase 1 precursor; EC 1.14.99.1; Cyclooxygenase- 1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1
Specific Function	May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells
Pathway	map00590 Prostaglandin and leukotriene metabolism
Reaction	arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O