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Active ingredient: Hydroxyurea - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

76.0547 g/mol

Physical State


Melting Point

142-146 oC

Water Solubility

1E+006 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameRibonucleotide reductase
Gene NameRRM1
SynonymsRibonucleoside-diphosphate reductase large subunit; EC; Ribonucleoside-diphosphate reductase M1 subunit; Ribonucleotide reductase large chain
General FunctionNucleotide transport and metabolism
Specific FunctionProvides the precursors necessary for DNA synthesis
Pathwaymap00230 Purine metabolism map00240 Pyrimidine metabolism
Reaction2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin

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