Brands, Medical Use, Clinical Data
- Anesthetic Adjuvants
- Permeabilizing Agents
Brands / Synonyms
Amphadase; Hyal-1; Hyaluronidase 1 precursor; Hyaluronidase PH-20; Hylenex Recombinant; Sperm adhesion molecule 1; Sperm surface protein PH-20; Vitrase (Ista Pharma)
Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
For increase of absorption and distribution of other injected drugs and for rehydration
Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Hyaluronidase is used for enhancing absorption and distribution of other injected drugs.
Mechanism of Action
Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
Biotrnasformation / Drug Metabolism