Brands, Medical Use, Clinical Data
Drug Category
- Anesthetic Adjuvants
- Permeabilizing Agents
Dosage Forms
Brands / Synonyms
Amphadase; Hyal-1; Hyaluronidase 1 precursor; Hyaluronidase PH-20; Hylenex Recombinant; Sperm adhesion molecule 1; Sperm surface protein PH-20; Vitrase (Ista Pharma)
Description
Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
Indications
For increase of absorption and distribution of other injected drugs and for rehydration
Pharmacology
Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Hyaluronidase is used for enhancing absorption and distribution of other injected drugs.
Mechanism of Action
Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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