Brands, Medical Use, Clinical Data
Drug Category
- Antiprotozoals
- Antimalarials
Dosage Forms
Brands / Synonyms
Halfan; Halofantrina [Inn-Spanish]; Halofantrine [Usan]; Halofantrinum [Inn-Latin]
Indications
For treatment of Severe malaria
Pharmacology
Halofantrine is a synthetic antimalarial which acts as a blood schizonticide. It is effective against multi drug resistant (including mefloquine resistant) P. falciparum malaria.
Mechanism of Action
The mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite.
Absorption
Not Available
Toxicity
Side effects incldue coughing noisy, rattling, troubled breathing, loss of appetite, aches and pain in joints, indigestion,and skin itching or rash.
Biotrnasformation / Drug Metabolism
Hepatic
Contraindications
Halofantrine should not be used if patient has atrioventricular
conduction disorders or Syncope,or thiamine deficiency or ventricular dysrhythmias
Drug Interactions
Not Available
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