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Active ingredient: Halofantrine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antiprotozoals
  • Antimalarials

Dosage Forms

  • Tablet

Brands / Synonyms

Halfan; Halofantrina [Inn-Spanish]; Halofantrine [Usan]; Halofantrinum [Inn-Latin]

Indications

For treatment of Severe malaria

Pharmacology

Halofantrine is a synthetic antimalarial which acts as a blood schizonticide. It is effective against multi drug resistant (including mefloquine resistant) P. falciparum malaria.

Mechanism of Action

The mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite.

Absorption

Not Available

Toxicity

Side effects incldue coughing noisy, rattling, troubled breathing, loss of appetite, aches and pain in joints, indigestion,and skin itching or rash.

Biotrnasformation / Drug Metabolism

Hepatic

Contraindications

Halofantrine should not be used if patient has atrioventricular conduction disorders or Syncope,or thiamine deficiency or ventricular dysrhythmias

Drug Interactions

Not Available

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