Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
Brands / Synonyms
Aminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Guanidine; Guanidine Hydrochloride; Guanidinium Chloride; Guanidinium Sulfate; Imidourea; Iminourea
Indications
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Mechanism of Action
Not Available
Absorption
Rapidly absorbed and distributed
Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Biotrnasformation / Drug Metabolism
Not metabolized.
Contraindications
Guanidine is contraindicated in individuals with a history of intolerance or allergy to this drug.
Drug Interactions
Not Available
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