Brands, Medical Use, Clinical Data
Brands / Synonyms
Aminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Guanidine; Guanidine Hydrochloride; Guanidinium Chloride; Guanidinium Sulfate; Imidourea; Iminourea
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Mechanism of Action
Rapidly absorbed and distributed
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Biotrnasformation / Drug Metabolism
Guanidine is contraindicated in individuals with a history of intolerance or allergy to this drug.