Brands, Medical Use, Clinical Data
Drug Category
- Sympatholytics
- Antihypertensive Agents
Dosage Forms
Brands / Synonyms
GBZ; Guanabenz Acetate; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy 8678 base; Wytensin
Indications
For management of High blood pressure
Pharmacology
Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.
Mechanism of Action
Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.
Absorption
Approximately 75% absorbed from gastrointestinal tract
Toxicity
Excessive contraction of the pupils, irritabilitylow blood pressure, sleepiness, slow heartbeat, sluggishness
Biotrnasformation / Drug Metabolism
Hepatic
Contraindications
Not Available
Drug Interactions
Not Available
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