Brands, Medical Use, Clinical Data
- Antihypertensive Agents
Brands / Synonyms
GBZ; Guanabenz Acetate; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy 8678 base; Wytensin
For management of High blood pressure
Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.
Mechanism of Action
Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.
Approximately 75% absorbed from gastrointestinal tract
Excessive contraction of the pupils, irritabilitylow blood pressure, sleepiness, slow heartbeat, sluggishness
Biotrnasformation / Drug Metabolism