Active ingredient: Guaifenesin - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Expectorants

Dosage Forms

• Liquid
• Powder for solution
• Syrup
• Tablet

Brands / Synonyms

Actifed-C; Aeronesin; Amonidren; Amonidrin; Anti-Tuss; Aresol; Balminil Expectorant; Benylin-E; Breonesin; Bromhist; Bronchol; Calmipan; Calmylin Expectorant; Colrex expectorant; Cortussin; Crantex; Creson; Diabetic Tussin EX; Dilex-G; Dilyn; Donatuss; Dorassin; Dyphylline GG; Equicol; Exall; Exall Liquid; Exefen; Fenesin; Flartussin; Gaiamar; Gee-Gee; Genatuss; Glycerin guaiacolate; Glycerin monoguaiacol ether; Glycero-guaiacol ether; Glycerol guaiacolate; Glyceryl guaiacol; Glyceryl guaiacol ether; Glyceryl guaiacolate; Glyceryl guaiacolate ether; Glyceryl guaiacyl ether; Glyceryl guaicolate; Glyceryl guiacolate; Glycodex; Glycotuss; Glytuss; Gnaifenesin; Guaia-rom; Guaiacol glycerin ether; Guaiacol glycerol ether; Guaiacol glyceryl ether; Guaiacolglicerinetere; Guaiacuran; Guaiacurane; Guaiacyl glyceryl ether; Guaiamar; Guaianesin; Guaicol glycerine ether; Guaicol glyceryl ether; Guaifenesin NR Liquid; Guaifenesin-DM NR Liquid; Guaiphenesin; Guaiphenesine; Guaiphesin; Guajacol-glycerinaether; Guajacuran; Guajamar; Guanar; Guayanesin; Guiaphenesin; Guiatuss; Gvaja; Halotussin; Humibid L.A; Humibid Sprinkle; Hustodil; Hustosil; Hycotuss; Hytuss; Hytuss-2X; Metfenossidiolo; Methoxypropanediol; Methphenoxydiol; Metossipropandiolo; Mintosyl; Miocaina; Miocurin; Miorelax; Mucinex; Mucostop; Muskurelax; Myocain; Myocaine; Myorelax; Myoscain; Myoscaine; Naldecon Senior EX; Neuroton; Neurotone; o-Methoxyphenyl glyceryl ether ; Oresol; Oreson; Organidin NR; Pneumomist; Propanosedyl; Reduton; Relaxil G; Relaxyl-G; Reorganin; Resil; Respenyl; Respil; Resyl; Ritussin; Robitussin; Scot-tussin Expectorant; Sinumist-SR; Sirotol; Tenntus; Tenntuss; Tolseron; Tolyn; Touro EX; Tulyl; Tulyn; Uni-tussin

Indications

Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

Pharmacology

Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.

Mechanism of Action

Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing.

Absorption

Rapidly absorbed from the GI tract

Toxicity

LD₅₀ 1510 mg/kg (rat, oral)

Biotrnasformation / Drug Metabolism

Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.

Contraindications

Hypersensitivity to any of the ingredients. The use of dextromethorphan-containing products are contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs).

Drug Interactions

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DRUG ABUSE AND DEPENDENCE

TUSSI-ORGANIDIN® NR* (* Newly Reformulated) Liquid: Controlled Substance- Schedule V Dependence- Codeine may be habit-forming.