Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
- Supplied as a sterile and totally biodegradable d,l-lactic and glycolic acids copolymer (13.3-14.3 mg/dose) impregnated with goserelin acetate equivalent to 3.6 mg of goserelin in a disposable syringe device fitted with a 16-gauge hypodermic needle
Brands / Synonyms
Goserelin acetate; Goserelin acetate (JAN/USP); Zoladex; Zoladex
Description
Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
Indications
Breast cancer; Prostate carcinoma; Endometriosis
Pharmacology
The pharmacokinetics of ZOLADEX have been determined in both male and female healthy volunteers and patients. In these studies, ZOLADEX was administered as a single 250µg (aqueous solution) dose and as a single or multiple 3.6 mg depot dose by subcutaneous route.
Mechanism of Action
ZOLADEX is a synthetic decapeptide analogue of LHRH. ZOLADEX acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.
Absorption
Inactive orally, rapidly absorbed following subcutaneous administration
Toxicity
No experience of overdosage from clinical trials
Biotrnasformation / Drug Metabolism
Hepatic
Contraindications
Not Available
Drug Interactions
Not Available
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