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Active ingredient: Gemfibrozil - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid

Chemical Structure

Molecular Weight

250.333 g/mol

Physical State


Melting Point

61-63 oC

Water Solubility

10 mg/mL (in base)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)


Primary Drug Target
NameExtrahepatic lipoprotein lipase (LL)
Gene NameLPL
SynonymsLipoprotein lipase precursor; EC; LPL
Specific FunctionThe primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium
Pathwaymap00561 Glycerolipid metabolism
Reactiontriacylglycerol + H2O = diacylglycerol + a carboxylate

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