Brands, Medical Use, Clinical Data
Brands / Synonyms
Acetic Acid Potassium Salt; Aisemide; Aldalix; Aldic; Aluzine; Anfuramaide; Apo-Frusemide; Apo-Furosemide; Aquarid; Aquasin; Arasemide; Beronald; Bioretic; Bristab; Bristurin; Cetasix; Depix; Desal; Desdemin; Di-Ademil; Dihydroflumethiazide; Dirine; Disal; Discoid; Disemide; Diucardin; Diumide-K; Diural; Diurapid; Diuretic Salt; Diurin; Diurolasa; Diusemide; Diusil; Diuzol; Dranex; Dryptal; Durafurid; Edemid; Edenol; Eliur; Elodrine; Endural; Errolon; Eutensin; Farsix; Finuret; Fluidrol; Fluss; Franyl; Frumex; Frumide; Frumil; Frusedan; Frusema; Frusemid; Frusemide; Frusemin; Frusenex; Frusetic; Frusid; Fulsix; Fuluvamide; Fuluvamine; Furanthril; Furanthryl; Furantril; Furanturil; Furesis; Furetic; Furex; Furfan; Furix; Furmid; Furo-Basan; Furo-Puren; Furobeta; Furocot; Furodiurol; Furodrix; Furomen; Furomex; Furomide M.D.; Furorese; Furosan; Furose; Furosedon; Furosemid; Furosemida [Inn-Spanish]; Furosemide "Mita"; Furosemide Injection; Furosemide [Usan:Inn:Jan]; Furosemidu; Furosemidu [Polish]; Furosemidum; Furosemidum [Inn-Latin]; Furosemix; Furoside; Furosifar; Furosix; Furoter; Furovite; Fursemid; Fursemida; Fursemide; Fursol; Fusid; Golan; Hissuflux; Hydol; Hydrenox; Hydrex; Hydro; Hydro-Rapid; Hydroflumethiazide; Hydroled; Impugan; Jenafusid; Katlex; Kofuzon; Kolkin; Kutrix; Lasemid; Lasex; Lasiletten; Lasilix; Lasix; Lasix Retard; Lasix Special; Laxur; Lazix; Leodrine; Less Diur; Liside; Logirene; Lowpston; Lowpstron; Luscek; Macasirool; Marsemide; Metflorylthiazidine; Methforylthiazidine; Mirfat; Mita; Moilarorin; Myrosemide; Naclex; Nadis; Nelsix; Neo-Renal; Nephron; Nicorol; Novosemide; Octan Draselny; Odemase; Odemex; Oedemex; Olmagran; Osyrol; Polysquall A; Prefemin; Profemin; Promedes; Promide; Protargen; Puresis; Radisemide; Radonna; Radouna; Retep; Rodiuran; Rontyl; Rosemide; Rosis; Rusyde; Sal Diureticum; Salinex; Salix; Salurex; Salurid; Saluron; Salutensin; Seguril; Selectofur; Sigasalur; Sisuril; Spirofur; Synephron; Transit; Trofurit; Uremide; Uresix; Urex; Urex-M; Urian; Uridon; Uritol; Urosemide; Vergonil; Vesix; Yidoli; Zafimida
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Mechanism of Action
Furosemide, by inhibiting the reabsorption of sodium and chloride in the ascending limb of the loop of Henle, increases the urinary excretion of sodium, chloride, and water. Furosemide also increases the excretion of potassium, hydrogen, calcium, magnesium, ammonium, and phosphate and, as it inhibits carbonic anhydrase, bicarbonate.
Biotrnasformation / Drug Metabolism
Furosemide is contraindicated in patients with anuria and in patients with a history of hypersensitivity to
Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of
impaired renal function. Except in life-threatening situations, avoid this combination.
Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
Patients receiving high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience
salicylate toxicity at lower doses because of competitive renal excretory sites.
Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the
action of succinylcholine.
Lithium generally should not be given with diuretics because they reduce lithium's renal clearance and add a high
risk of lithium toxicity.
Furosemide may add to or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs
with ganglionic or peripheral adrenergic blocking drugs.
Furosemide may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used
Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive
effects of furosemide. Patients receiving both drugs should be observed closely to determine if the desired diuretic
and/or antihypertensive effect of furosemide is achieved. The intake of furosemide and sucralfate should be separated
by at least two hours.
Tablets, Injection, and Oral Solution
One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily
reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who
developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in
conjunction with NSAIDs.
Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive
effects of furosemide in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma
renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and
furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of
furosemide is achieved.