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Active ingredient: Fosfomycin - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C3H7O4P

Chemical Name

(3-methyloxiran-2-yl)phosphonic acid

Chemical Structure

Molecular Weight

138.059 g/mol

Physical State

Solid

Melting Point

94 oC

Water Solubility

50 mg/mL (Sodium salt)

Isoelectric Point

Not Available

Organisms Affected

E. coli and other enteric bacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameUDP-N-acetylglucosamine 1-carboxyvinyltransferase
Gene NamemurA
SynonymsEC 2.5.1.7; Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT
General FunctionCell wall/membrane/envelope biogenesis
Specific FunctionCell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin
Pathwaymap00530 Aminosugars metabolism
Reactionphosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine

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