Active ingredient: Fosfomycin - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Anti-Bacterial Agents

Dosage Forms

• Powder

Brands / Synonyms

Fosfocina; Fosfomycin disodium salt; Fosfomycin sodium; Fosfonomycin; Monurol; Phosphomycin; phosphomycin disodium salt ; Phosphonomycin; Veramina

Indications

For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.

Pharmacology

Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.

Mechanism of Action

Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall.

Absorption

Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%

Toxicity

LD₅₀>5 g/kg (rats). Side effects may include diarrhea

Biotrnasformation / Drug Metabolism

No transformation, excreted unchanged

Contraindications

Not Available

Drug Interactions

Not Available