Active ingredient: Foscarnet - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

CH3O5P

Chemical Name

phosphonomethanoic acid

Chemical Structure

Molecular Weight

126.005 g/mol

Physical State

Solid

Melting Point

88.06 oC

Water Solubility

Complete

Isoelectric Point

Not Available

Organisms Affected

Human herpes viruses

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not applicable

Primary Drug Target

Name	DNA polymerase (human herpes simplex virus 1)
Gene Name	UL30
Synonyms	DNA polymerase; EC 2.7.7.7
General Function	Replication, recombination and repair
Pathway	map00230 Purine metabolism map00240 Pyrimidine metabolism map03030 DNA polymerase
Reaction	deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)