Active ingredient: Flutamide - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

• Androgen Antagonists
• Antineoplastic Agents, Hormonal

Dosage Forms

• Tablet

Brands / Synonyms

Cebatrol; Eulexin; Flutamide USP25; FTA; Niftholide; Niftolide

Indications

For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate

Pharmacology

Not Available

Mechanism of Action

Flutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.

Absorption

Rapidly and completely absorbed.

Toxicity

The most common side effect is gynecomastia

Biotrnasformation / Drug Metabolism

Flutamide is rapidly and extensively metabolized, with flutamide comprising only 2.5% of plasma radioactivity 1 hour after administration.

Contraindications

EULEXIN Capsules are contraindicated in patients who are hypersensitive to flutamide or any component of this preparation.

EULEXIN Capsules are contraindicated in patients with severe hepatic impairment (baseline hepatic enzymes should be evaluated prior to treatment.

Drug Interactions

Increases in prothrombin time have been noted in patients receiving long- term warfarin therapy after flutamide was initiated. Therefore, close monitoring of prothrombin time is recommended and adjustment of the anticoagulant dose may be necessary when EULEXIN Capsules are administered concomitantly with warfarin.