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Active ingredient: Fluphenazine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antipsychotics
  • Phenothiazines

Dosage Forms

  • Liquid

Brands / Synonyms

Anatensol; Apo-Fluphenazine; Elinol; Fluorfenazine; Fluorophenazine; Fluorphenazine; Fluphenazine Decanoate; Fluphenazine Hcl; Modecate; Modecate Concentrate; Moditen; Moditen Enanthate; Moditen Hcl; Omca; Pacinol; Permitil; Permitil Concentrate; Perphenazine; Pms Fluphenazine; Prolixin; Prolixin Concentrate; Prolixin Decanoate; Prolixin Enanthate; Prolixine; Sevinol; Siqualine; Siqualon; Tensofin; Triflumethazine; Valamina; Vespazine; Yespazine


For management of manifestations of psychotic disorders.


Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.

Mechanism of Action

Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.


Not Available


Not Available

Biotrnasformation / Drug Metabolism

Not Available


Phenothiazines are contraindicated in patients with suspected or established subcortical brain damage, in patients receiving large doses of hypnotics, and in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride. Fluphenazine hydrochloride is contraindicated in patients who have shown hypersensitivity to fluphenazine; cross-sensitivity to phenothiazine derivatives may occur.

Drug Interactions

No information provided.

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