Active ingredient: Fluorouracil - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C4H3FN2O2

Chemical Name

5-fluoro-1H-pyrimidine-2,4-dione

Chemical Structure

Molecular Weight

130.077 g/mol

Physical State

Solid

Melting Point

280-282oC

Water Solubility

< 0.1 g/100 mL at 19 °C

Isoelectric Point

8.02

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP1A2

Primary Drug Target

Name	Thymidylate synthase
Gene Name	TYMS
Synonyms	EC 2.1.1.45; TS; TSase
General Function	Nucleotide transport and metabolism
Pathway	map00240 Pyrimidine metabolism map00670 One carbon pool by folate
Reaction	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP