DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Active ingredient: Flucytosine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C4H4FN3O

Chemical Name

4-amino-5-fluoro-pyrimidin-2-ol

Chemical Structure img=Flucytosine_APRD00299_ZOOM.gif

Molecular Weight

129.093 g/mol

Physical State

Solid

Melting Point

296 oC

Water Solubility

10.5 g/L

Isoelectric Point

3.26

Organisms Affected

Yeast and other fungi

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameThymidylate Synthase
Gene NameTMP1
SynonymsThymidylate synthase; EC 2.1.1.45; TS; TSase
General FunctionNucleotide transport and metabolism
Specific FunctionSynthesizes thymidylic acid in the de novo biosynthetic pathway. It catalyzes the final step in the de novo synthesis of deoxy-thymidine monophosphate using the substrate dUMP and a cofact 5,10-methylene tetrahydropfolate. It is essential to DNA replication in humans.
Pathwaymap00240 Pyrimidine metabolism map00670 One carbon pool by folate
Reaction5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017