Chemisty and Biological Activity
Chemical Formula
C4H4FN3O
Chemical Name
4-amino-5-fluoro-pyrimidin-2-ol
Chemical Structure
img=Flucytosine_APRD00299_ZOOM.gif
Molecular Weight
129.093 g/mol
Physical State
Solid
Melting Point
296 oC
Water Solubility
10.5 g/L
Isoelectric Point
3.26
Organisms Affected
Yeast and other fungi
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | Thymidylate Synthase | Gene Name | TMP1 | Synonyms | Thymidylate synthase; EC 2.1.1.45; TS; TSase | General Function | Nucleotide transport and metabolism | Specific Function | Synthesizes thymidylic acid in the de novo biosynthetic pathway. It catalyzes the final step in the de novo synthesis of deoxy-thymidine monophosphate using the substrate dUMP and a cofact 5,10-methylene tetrahydropfolate. It is essential to DNA replication in humans. | Pathway | map00240 Pyrimidine metabolism
map00670 One carbon pool by folate | Reaction | 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP |
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